University of Hong Kong, Hong Kong
Title: Gut microbiome modulation in patients suffering from Irritable Bowel syndrome following faecal microbiota transplantation
The microbiome plays a crucial role in maintaining homeostasis in the human gut. Faecal Microbial transplant (FMT) is a process of transferring microbial communities from a healthy donor to a recipient; consequently, it is now being widely investigated for its ability to improve various health issues associated with gastrointestinal diseases. In this study, we investigated changes in gut microbiota following FMT in a patient with Irritable Bowel Syndrome (IBS). We describe changes in the composition of the faecal microbiome from a patient recipient before and after undergoing FMT, as a treatment for IBS condition. There was a marked loss of bacterial diversity with reduced bacterial phylum belonging to Firmicutes prior to FMT, this was corrected after post-FMT. Furthermore, an additional 13 donor bacterial species were engrafted after post-FMT belonging to Actinobacteria, Bacteroidetes and Firmicutes phylla. The observed changes in the host-gut environment following FMT procedures highlights changes in community structure dynamics reflecting changes needed for restoring a healthy and balanced gut microbiome.
Keywords: Microbiome, fecal microbiota transplant, Irritable Bowel Syndrome (IBS).